- Any patient with Gleason Score > or = 8 who has a life expectancy of > 5 year
- Any Patient with Locally Advanced Disease ( T3 , T4 ) who has a life expectancy of > 5 year
- Any patient with localized but palpable disease ( T2 ) with PSA > 10 with life expectancy of > 5 year
- Any Patient with PSA > 20 who has a life expectancy of > 5 year
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